Intravenous insulin infusion has demonstrated its efficacy in reducing triglyceride levels, particularly in cases of pancreatitis. This case series explores the application of intravenous insulin therapy in diverse clinical scenarios, where hospitalized patients presented with hypertriglyceridemia concurrent with various ailments. Remarkably, all patients exhibited positive responses to the treatment, resulting in the successful reduction of triglyceride levels to within the near-normal to normal range. This study sheds light on the broader potential of intravenous insulin in managing hypertriglyceridemia across different medical conditions, presenting a promising avenue for therapeutic intervention.