Background: Psoriasis is a chronic inflammatory skin disease affecting 1-3% of the general population with psoriatic arthritis occurring in 5-40% of psoriatic cases. Several studies have shown that anxiety and Depression is also part of chronic inflammation. The present study aimed to assess the relationship of psoriasis with anxiety symptoms and Depression in Indian patients. Material & Method: This case-control study was carried out in Indian patients with psoriasis vulgaris and healthy control attending to dermatology department of tertiary care hospital during the period of June 2022 to December 2022. The patients with diagnosis of psoriasis consenting to be part of study were included in the present study. The psoriasis was assessed using PASI scoring, anxiety by Generalized Anxiety Disorder 7-Item (GAD- 7) scale, and depression by Patient Health Questionnaire (PHQ-9) scale. All the data were collected and analysed to assess the relation of anxiety and depression symptoms in patients with psoriasis. Result: Total of 100 participants included with 50 each in case and control group. The patients were comparable with no significant difference in demographic details between the groups. There is higher odds of developing depression and anxiety among the patients with psoriasis compared to the healthy participants. (p<0.05) In patients with late onset psoriasis vulgaris there was significant association with a higher risk of depression symptoms and anxiety as compared to the controls. (p<0.05). Conclusion: Psoriasis vulgaris patients were more likely to develop depression and anxiety compared to healthy participants. Late-onset patients with psoriasis were positively associated with anxiety and depression.