Background:The present study was conducted for evaluating body fluids with conventional smear and cell block at tertiary care hospital.Materials & methods:The present study was conducted on 50 body fluid samples (pleural, synovial, ascitic fluid) from patients were analysed in the cytopathology laboratory of our institute.All 50 fluid specimens were examined for conventional cytological smear (CS) and cell block method (CB). Each fluid specimen was divided in two equal portions with one portion subjected to conventional smear technique, Smear was immediately fixed with 95% alcohol and stained with Haematoxylin-Eosin (H&E). The other part was subjected to 10% alcohol-acetic acid-formalin cell block technique. Paraffin- embedded 4-6 μ thick sections were routinely stained with H&E.The morphological characteristics, cellularity, nuclear and cytoplasmic details were evaluated in both CS and CB techniques.Results:10 cases were malignant positive for both smear and cell block, 5 cases were suspicious for malignancy for smear and were positive for malignancy on evaluation in cell block, 6 cases of mesothelial cluster which were positive for malignancy in conventional smear were negative on evaluation from cell block, 29 cases were benign on evaluation from both smear and cell block.Conclusion:The study found that methods had high specificity. Cell- blocks were found to be more reliable to smears in typing malignancy.