Background: Giant cell tumor (GCT) of bone is a well-defined tumor with a nonsclerotic margin. Commonly it is described as an eccentrically expansile lytic lesion placed located in the metaphyseal epiphyseal junction. The commonest site of occurrence in order is distal femur, proximal tibia, proximal humerus, distal ulna and radius. Cases have been reported as it can occur in small bones of hand and feet. Distal end of femur, can sometimes extend to the articular surface, and most often occurs in patients with closed physis. Materials and methods: Our study is a prospective design with 21 cases of giant cell tumours of long bones. All the cases were evaluated thoroughly and all the patients underwent effective surgical management with a follow up of upto 5-8 years. Results: All cases were analyzed based on age, site of occurrence, presentation with first symptoms and further evaluated by Musculoskeletal Tumor Society Score. All cases had good outcome at final follow-up except in one case who reported with local recurrence. Conclusion: Wide surgical excision / Thorough curettage of the lesion without leaving any residual tumor tissue constitute the mainstay of success in clearing GCT lesions.