Background: Implant associated Surgical site infection are a considerable concern in clinical practice due to their potential complication and adverse outcome. They can lead to significant morbidity, increased healthcare cost, prolonged hospital stays and even implant failure. Methods: All the patients of Open Reduction and Internal Fixation were enrolled for the study. The study was done in Department of Microbiology, Bundelkhand Medical College, hospital, Sagar, Madhya Pradesh. Result: The study was done in 138 patients. In the present study, the most common location for the fracture was the distal femur (29.7%). The most common age group was 40-60 yrs (33.2%).The most common bacteria in the present study was Staphylococcus aureus (54.3%) followed by E. coli (18.1%) and Pseudomonas aeruginosa (12.5%). Conclusion: Implant associated Surgical site infection is a significant complication in orthopedic patients. By understanding the nature of these infections and implementing preventive measures, healthcare professionals an minimize the occurrence of Implant associated Surgical site infection and improve patient outcome.