Background: The present study was undertaken for comparing the efficacy of combined Supraclavicular-Interscalene Block versus Interscalene Block Under Ultrasound Guidance in Patients Undergoing Humerus Shaft Fracture Surgery. Materials & Methods: A total of 50 patients of ASA group I & II within the age range of 20 to 60 years were enrolled. Group A: Patients who received combined Supraclavicular-Interscalene Block and Group B: Patients who received Interscalene Block. Both performed with the use of ultrasound localization. The stimulating needle was inserted perpendicular to the skin's surface and pointed toward the suspected nerve structures for both blocks, which allowed for the best possible visualization of the vascular and neurological systems. All the results were recorded in Microsoft excel sheet followed by statistical analysis. Results: Mean procedural time among patients of group A and group B was 212.7 seconds and 192.3 seconds respectively. non-significant results were obtained while comparing the degree of sensory block. However, while comparing the degree of ulnar motor block in between the study groups, significant results were obtained. Non-significant results were obtained while comparing duration of anaesthesia & postoperative analgesia (mins). Conclusion: Under ultrasound supervision, brachial plexus blocks can be used in conjunction to safely limit the need for analgesic and anesthetic drugs in order to achieve complete upper extremity pain relief following surgery without putting the patient at further risk of local anesthetic toxicity.