Aim: The aim of this study is to compare the effectiveness of Amoxiclav and Levofloxacin in the treatment of acute sinusitis. Materials and Methods: Patient’s aged more than 18 years presenting with signs and symptoms of acute maxillary sinusitis were included in the study. The patients were divided into two groups. In Group I patients 1gm of amoxicillin-clavulanate was given two times a day and in Group II, 500 mg of levofloxacin was given once a day for a period of 7 days. Patient’s complete demographic details were recorded including name, age and gender. Xylometazoline nasal spray and steam inhalations were given to all the patients. Assessment of all the patients was done for resolution of signs and symptoms. Results: In this study a total of 220 participants were included. Group I consisted of 110 participants who received amoxiclav, whereas Group II consisted of participants who were given levofloxacin. The majority of participants in both groups fell within the age range of 35-45 years. In Group I, 40.91% of individuals belonged to this age group, whereas in Group II, the percentage was 45.45%. The therapy's clinical result revealed that 53.64% of patients in Group I and 50.91% of cases in Group II achieved full cure. Group I had a 31.82% increase in cases, whereas Group II had a 26.36% increase in cases. In Group I, there was no improvement seen in 14.55% of instances, whereas in Group II, no improvement was recorded in 22.73% of cases. Conclusion: The current investigation found that Amoxiclav was more effective than levofloxacin in treating the cases. The efficacy of amoxiclav was also enhanced in the improved patients. The incidence of unsuccessful outcomes was higher with levofloxacin. This demonstrates that the clinical result achieved with amoxiclav was superior to that achieved with levofloxacin.