Background: To assess the tolerability of Cilnidipine and Amlodipine in the treatment of hypertension.Materials & Methods:A total of 40 patients with newly diagnosed mild to moderate hypertension. Comprehensive demographic information was collected for all participants. A complete evaluation of the cardiovascular and respiratory systems was also performed. Follow-up examinations took place at the 2nd, 4th, and 6th weeks. All data were recorded in a Microsoft Excel sheet and subjected to statistical analysis using SPSS software. The significance level was assessed using the Student t-test and chi-square test.Results:Forty patients were included in the study, divided evenly into two groups, with 20 patients in each group. The mean age of patients in Group C and Group A was 46.2 years and 40.2 years, respectively. Comparing the tolerability of the drugs between the two study groups yielded non-significant results.Conclusion:Patients experiencing hypertension demonstrated greater tolerability with Cilnidipine when contrasted with Amlodipine.