Background: Obesity is the result of complex relationship between food consumption patterns, lifestyle habits, socioeconomic, cultural, urban development, certain diseases or pharmacological treatment and genetics. Single-nucleotide polymorphisms(SNP) present in particular genes are associated with eating behavior in obese individuals. SNP of melanocortin -4 receptor (MC4R) gene was found to contribute satiety responsiveness and eating in the absence of hunger leading to childhood and adolescent obesity. Aim: To analyze the presence SNP of MC4R gene(rs17782313 CC genotype) in young obese and to find its association with BMI ≥ 30 kg/m² and waist hip ratio. Materials and Methods: This case control study was done at KAP Vishwanatham Government Medical college,Trichy, during the period of JUNE 2020 – MAY 2021. Total 35 young obese adults BMI ≥ 30 kg/m² in the age group of 15-25 years and age and sex matched 35 controls were included in the study. Data from all the individuals for blood pressure, anthropometric and biochemical characteristics were obtained, and single nucleotide polymorphism of MC4R gene (rs17782313 CC genotype) was assessed by PCR RFLP. Results: Genotype and allele distribution in controls and cases finds CC genotype,C allele distribution was higher in obese cases with high statistical significance (p < 0.0001). The logistic regression analysis for C allele at rs 17782313 had odds ratio of 4.03 with 95 % confidence interval and p value of 0.001. As body mass index increases, the risk of development of obesity increases. This is evidenced in our study as statistical significance is in positive correlation between body mass index and obesity. Conclusion: Findings in present study, suggest the statistical significant association of single nucleotide polymorphism of MC4R gene with presence of C allele for T allele at rs 17782313 and obesity.