Aim: To evaluate the Role of Neutral pH Super Oxidised Solution in the Treatment of Diabetic Foot Ulcers. Materials and Methods: A total of 220 patients diagnosed with Meggit Wagner Grade I and Grade II diabetic foot ulcers (DFU) were included in the study. The patients were divided into two groups, with 110 patients randomly allocated to either the SOS group or PI group. Patients diagnosed with diabetic foot ulcers (DFUs) of Wagner grade I and II, with ulcer dimensions less than 100cm2, were included in the study. The measurement of the target ulcer's area, specifically the result, was conducted by the use of Plannimetry, using a clear graph sheet. The results were computed using a student's t-test. The assessments were conducted on days 1,7, 14, and 21. Results: The alteration in wound dimensions from the first measurement (Day 1) was evaluated at day 7, day 14, and day 21. There was no notable difference in wound size between Group A (SOS) and Group B (PI) at day 1-7 (t=0.89, p=0.22) and day 1-14 (t=2.05, p=0.07). However, a significant difference was seen at day 21, with Group A (SOS) showing a larger reduction in wound size compared to Group B (PI) (t=12.44, p<0.001).The average percentage reduction in wound size at Day 21 was 36.36% in Group A (SOS) and 20% in Group B (PI). A notable disparity was seen between Group A (SOS) and Group B (PI) in the ANOVA analysis regarding the average length of hospital stay. In Group A (SOS), the average length for the appearance of Granulation tissue on the Day was 5.17±0.62 days, while in Group B, the average duration for the appearance of Granulation tissue on the Day was 7.08 ± 0.96 days. The average length of hospital stay in Group A (SOS) was 13.25 ± 1.88 days. The average length of hospital stay in Group B (PI) was 16.37 ± 2.06 days. Conclusion: The neutral pH super oxidised solution is a safe and efficient wound care medication that effectively disinfects wounds, promotes the production of granulation tissue, and accelerates the healing process in the treatment of diabetic foot ulcers (DFU).