Aim: To compare the pattern of smartphone, use among the students of different streams of medical university i.e. medical, dental, nursing and pharmacy. Methodology: Thestudentsstudyinginvariousstreams of Medical university i.e. medical, dental, nursing and pharmacy(n=100 each) wereprovidedwith Semistructured proforma,Smartphone Addiction Scale (SAS-SV), and Modified Kuppuswamy's Socioeconomic Scale:2018. They were given instructions regarding each proforma and response on each item to bemade was emphasized. Ten heavy users from each stream of undergraduate students who consented for personality assessment, were assessed further for personality profile using NEO - FFI scale. Results: SAS score was found to be significantly correlated with the DAS-S score (i.e. for stress) in all the study groups individually as well as overall. Such significant correlation for anxiety score, i.e. DAS-A with SAS, was observed for medical, dental as well as overall study sample. On the NEO-FFI scale, Neuroticism was found to be high in majority of dental (70%), nursing (70%) and pharmacy (90%) students but not among medical students. Score for Extraversion was found to be average for majority of students in all the study groups. Most of the students in all the study groups were found to be having high score for Openness, but the score was low in case of Agreeableness and Conscientiousness for most subjects in each group. Overall, there was no significant difference in any of the domains of NEO-FFI between the study groups. Conclusion: Psychiatrists need to be sensitized to the various issues of those afflicted with smartphone addiction, and must evaluate it and provide appropriate interventions for reducing their addiction level and thereby improving their quality of life.