Background: The present study was conducted for examining the association of high-sensitive C-reactive protein (hs-CRP) and lipid profile in early phase acute coronary syndrome (ACS) patients. Materials & Methods: A total of 200 patients with ACS and 100 healthy controls were enrolled in the present study. A Performa was made and detailed clinical profile, demographic details and medical history of all the patients was recorded. All patients with ACS with divided into two study groups as follows: Early onset group: Onset of ACS symptoms in less than 6 hours, and Late onset group: Onset of ACS symptoms in between 6 hours to 24 hours. Blood samples were obtained within 24 hours from onset of symptoms and were sent to laboratory. Auto-analyzer was used for evaluation of serum lipid profile and hs-CRP levels. Results: Mean hs-CRP levels among ACS patients and controls was found to be 8.32 mg/L and 1.13 mg/L respectively. Mean serum lipid profile was significantly deranged among ACS patients in comparison to healthy controls. Also, while comparing the hs-CRP levels among patients of early onset ACS and late onset ACS group, significant results were obtained. While evaluating and comparing the lipid profile among early onset ACS patients and late onset ACS patients, significant results were obtained. Conclusion: The higher mortality and morbidity may be caused by the ACS patients' changed lipid profiles and noticeably higher levels of the inflammatory marker hs-CRP compared to controls.