Background: A typical skin cell takes a month to fully develop and shed.1 Skin cells in psoriasis only take three to four days to complete this. The skin cell builds up on the skin's surface rather than shedding. Psoriasis plaque is said by some people to itch, burn, and sting, Scales and plaques can develop anywhere on the body. Materials & Methods: 90patients of psoriasis of both genders were divided into 2 groups of 40 each.Psoriasis area severity index (PASI) was assessed in both groups. Results: Common clinical features were scaling seen in 16 in group I and 14 in group II,red lesion seen 12 in group I and 13 in group II, burning pain seen 8 in group I and 11 in group II, thick lesions seen 9 in group I and 6 in group II, it chin seen in 27 in group I and 24 in group II and joint pain seen in 12 in group I and14 in group II respectively. The difference was non-significant (P>0.05). Conclusion: Authors found that Methotrexate found to be superior than clobetasol propionate. Combination therapy is more effective in management of cases of psoriasis.