Background: Propofol is a common intravenous drug for anaesthetic use which is responsible for distressing pain at the site of injection. Pre medication with Ketamine is one of the methods recommended to alleviate the pain at the site of Propofol injection because of its local anaesthetic characteristic. The purpose of this study was to determine the efficacy of a low dosage (100 mcg/kg body weight) intravenous Ketamine in reducing intravenous Propofol injection pain using the McCrirrick and Hunter scale. Materials and Methods: Total 88 adult patients of American Society of Anesthesiologists (ASA) Physical status I and II of both genders undergoing elective surgical procedure under general anaesthesia were randomly assigned into two groups. Group-A has 44 patients who were Pre-treated with Ketamine 100 mg/kg body weight or 1ml where as Group- B with same number of patients (44 patients) were pre-treated with 0.9% of Normal Saline or 1ml. Both, group A and group B were evaluated using McCrirrick and Hunter method at 5,10 and 15 seconds of interval. Results: The comparison of groups A and B using the McCrirrick and Hunter Evaluation Scale at 5, 10, and 15 second intervals was statistically significant (p value 0.005). In comparison to group B, none of the individuals in group A suffered moderate or severe pain at all three periods. Mc Crirrick and Hunter assessment score’s mean values were statistically significant across all time periods. The two group’s hemodynamic parameters, EtCO2 and SpO2 were equivalent. There was no evidence of any negative consequences in either group. Conclusion: Intravenous Ketamine injection at a dosage of 100mcg/kg body weight with a tourniquet as a pretreatment before Propofol was effective in considerably lowering the occurrence and severity of pain while having no adverse haemodynamic impact.