Objective: Hyperemesis gravidarum (HG) represents an abnormal response of gravid women to pregnancy itself. The cause of hyperemesis is obscure, and there are conflicting data regarding the relationship between the disease itself with serum HCG levels and thyroid functions. Hyperparathyroidism, one of the reasons for intractable vomiting, can also be a differential diagnosis of hyperemesis and needs early identification. Additionally, women suffering from hyperemesis might have psychological counterparts. Methods: In this prospective case-control study, we have tried to evaluate the existence of any relationship between serum biochemical markers and depression scoring of pregnant women with the disease process of hyperemesis. Result: 33[66%] and 27[54%] women admitted with hyperemesis were found to possess high serum beta-HCG and abnormal thyroid function. Only one was detected with a high calcium level. A statistically higher number of women with hyperemesis were revealed to suffer from a low to severe form of depression. Conclusion: Though statistically higher numbers of women with hyperemesis were found to possess high serum beta-HCG and abnormal thyroid function in contrast to controls, more notably, a significant number of them do not show these aberrations implying the fact that these hormones cannot be considered as any form of universal straightway bio-marker for HG. Contrary to our speculation, serum calcium level estimation reveals no importance in women with hyperemesis. Depression score is found to be significantly higher in women presenting with hyperemesis. Thus, determining psychological status should remain an integral to evaluating this disease.