Background: To study the efficacy of topical hyaluronic acid with betadine compared to betadine alone. Materials & methods: A total of 100subjects were enrolled. They were divided into two groups as test (Hyaluronic acid with betadine group) and control group (Betadine alone group) with 50 in each. Outcome was evaluated. The results were analysed using SPSS software. Results: A total of 100 subjects were enrolled. 8 subjects (of controls) underwent subsequent limb amputation whereas no patient in case group underwent amputation.Results revealed that wound healing was better in study group adjunct to control, non significant VAS score association and relatively shorter hospital stay was found in study group. Conclusion: Topical hyaluronic acid with betadine could be considered as an adjunct to betadine in local wound management