Cotton wool spots are seen by ophthalmoscopy as a result of microinfarction of nerve fibre layer of the retina. In AIDS these lesions usually are confined to the posterior pole near optic disc. Cotton wool spots are ophthalmoscopically visible for 6 to 12 weeks owing to the transient nature of lesion and it is apparent noninfectious cause, treatment not indicated. All patients who were attending ART center who are on HAART were screened for HIV retinopathy. Patients found to have retinal changes were evaluated further in Ophthalmology OPD. We also found that visual dysfunction was more common with patients who had less CD4 count. In our study abnormal contrast sensitivity was present in 10 patients and 5 out of 10 were in 1-100 cells/µl range and 3 were in 100-200cells/µl group.