Background: The present study was conducted for comparing the analgesic effect of Ibuprofen versus Ketoralac on post operative pain following surgical Extraction. Materials & methods: 80 patients were enrolled which complained of postoperative pain after the surgical removal of impacted third molars. All the 80 patients were randomly assigned into two study groups with 40 patients in each group as follows: Group 1: Patients receiving oral doses of ketorolac tromethamine 10 and 20 mg and,Group 2: Patients receiving oral doses of ibuprofen 400 mg. Using a self-rating record, subjects rated their pain and its relief hourly for 6 hours after medicating. Pain was assessed on a scale of 0 to 10 with 0 indicating no pain and 10 indicating maximum unbearable pain. All the results were recorded in Microsoft excel sheet followed by statistical analysis using SPSS software. Results: Among group 1 subjects, mean VAS at immediate postoperative, 6 hours postoperative, 12 hours postoperative, 18 hours postoperative and 24 hours postoperative time period was 4.3, 2.6, 2.3, 1.9 and 1.2 respectively while among group 2 subjects mean VAS at immediate postoperative, 6 hours postoperative, 12 hours postoperative, 18 hours postoperative and 24 hours postoperative time period was 4.1, 2.4, 2.9, 1.5 and 1.1 respectively. While comparing the results statistically, non-significant results were obtained. Conclusion: Both the drugs were equally effective in providing postoperative pain relief among patients undergoing third molar extraction surgery.