In this prospective randomized trial, the efficacy and safety of intravaginal Misoprostol and intracervical dinoprostone gel for the induction of labor in cases of an unfavorable cervix were compared. One hundred women with an unfavorable cervix requiring labor induction were randomly assigned to receive either 25 µg of vaginal Misoprostol every 4 hours or 0.5 mg of intracervical dinoprostone every 12 hours. The study measured the change in Bishop's score, the percentage of women who went into labor, induction-to-delivery interval, the need for oxytocin, mode of delivery, and complications.The parity, mean gestational period, and initial Bishop's score were similar in both groups. However, the Misoprostol group showed significantly better improvement in the Bishop's score at 12 hours. The induction-to-delivery interval was also significantly shorter in the Misoprostol group, with a mean duration of 16.49 ± 5.13 hours compared to 27.67 ± 12.71 hours in the dinoprostone group. The rate of complications was comparable between the two groups. Therefore, the study concluded that vaginal Misoprostol at a dosage of 25 µg every 4 hours is a safe and effective method for labor induction and is associated with a shorter induction-to-delivery interval.