The novel coronavirus, SARS CoV-2, was first discovered in Wuhan, China in December 2019 and resulted in a worldwide pandemic spreading to at least 226 countries and territories with > 500 million confirmed cases, and causing > 6 million deaths. The global pandemic of COVID -19 caused by severe acute respiratory syndrome coronavirus [SARS-CoV 2] had patients presenting with Post-COVID syndrome which refers to the presence of a variety of symptoms that range beyond the acute phase of COVID-19 infection. These chronic sequelae diminish the individual’s functional capacity. Data from the SARS pandemic of 2002 to 2004 identified muscular and bone dysfunction in moderate and severe infections. Studies have shown musculoskeletal dysfunction in some patients with COVID-19 however the exact mechanism of this has not yet been identified. The purpose of this article is to summarise the proposed musculoskeletal effects involving skeletal muscle, bone, joint, cartilage, and tendon, following SARS CoV-2 infection and the pathophysiology related to these effects.