Background: Soluble fms liketyrosinekinase1 (sFlt-1) antagonizes vascularendothelial functionsleadingtohypertensive disorders of pregnancy. Aims: The aim of this studyis tofindtheassociationbetweensoluble fms liketyrosinekinase1and incidence of preeclampsia amongprimigravida. Materials and Methods: This cross sectional study was conducted at Raja Mirasudar Hospital, Thanjavur, during the period of June 2016 to December 2016. Study population total of 90 cases primigravida. Blood sample were assessed for ALT, AST,Creatinine, Platelet count and sFlt-1. Data was entered and analyzed using Statistical Package for Social Sciences (SPSS) version 20. Descriptive statistics, chi square tests, relative risk and ANOVA were used, appropriately to calculate the statistical significance. P value of < 0.05 was considered as statistically significant. Results: sFlt levels were normal and elevated in 78.9% and 21.1% of cases, respectively and there were 5.6% and 18.9% of cases with eclampsia and pre-eclampsia, respectively. We found statistically significant association with relative risk (RR) of 23.7 between sFlt levels and presence or absence of preeclampsia and eclampsia. The mean difference in sFlt levels among preeclampsia and eclampsia cases were found to be statistically significant. Conclusion: From this study,it is found that the primigravida with increasedserums Flt levels haddeveloped Preeclampsia in the laterpregnancy and few of themdeveloped Eclampsia. serum sFlt levels can be used to predicttheoccurrenceofbothpreeclampsiaandprogression toeclampsia.