Background: The present study was conducted for analyzing renal profile in patients with liver disease. Materials & methods: A total of 100 patients were enrolled. Detailed history and clinical examination were done. Relevant blood investigation like Hemogram, peripheral blood smear for band forms, Urine analysis under microscopy and routine, protein, Blood urea and serum creatinine at admission was done. Serum electrolytes, Ultrasonography abdomen, ABG if required, Central venous pressure and other investigations to exclude diseases causing liver and renal failure was performed on day of admission and patient was follow up every month till 6 months. Data was collected according to a predefined protocol (proforma). Demographic characteristics, risk factors, family history, neurological examination, diagnostic data and treatment details was collected. Results: Mean blood urea levels and serum creatinine levels were found to be 41.87 mg/dL and 1.39 mg/dL respectively. Out of 100 patients, 3 percent of the patients belonged to Child Pugh score A while 51 percent of the patients and 46 percent of the patients (46 patients) belonged to Child Pugh score B and Child Pugh score C respectively. Abnormal serum urea levels and serum creatinine levels were seen in 31 percent of the patients each. Mean serum creatinine levels at Day 1 and Day 3 were 1.25 mg/dL and 1.58 mg/dL respectively. Conclusion: Patients with liver diseases have significant deranged renal profile.