Background: The present study was conducted for assessing the flexural strength of denture base resin materials processed using compression molding technique and injection molding technique. Materials & methods:20 denture base resin specimens were included and were divided into two study groups with 10 specimens in each group: Compression molding group and injection molding group. Specimens were fabricated with standardization done using metal strips. Conventional techniques were used for polishing and finishing. After polishing, all specimens were checked for their dimensions with a digital calliper. Thermocycling was carried out. The Flexural strength of fracture resistance was measured on a computerized, software-based Universal Testing Machine. All the results were recorded in Microsoft excel sheet followed by statistical analysis using SPSS software. Results:Mean flexural strength of specimens of conventional molding group was 75.35 MPa while that of injection molding group was 89.12 MPa. Significant results were obtained while comparing the mean flexural strength of specimens of both the study groups. Conclusion:Flexural strength of denture base resin materials processed using injection molding technique is better than that of compression molding technique.