Background: Neo-adjuvant chemotherapy is employed for patients with locally advanced breast carcinoma and in cases of metastatic or inoperable breast carcinoma to reduce tumor size and subsequently improve breast-conserving surgery rates. Biomarker studies performed on excisional specimens may be discordant with those performed on trucut biopsy, moreso after neo-adjuvant chemotherapy. There is paucity of data in the literature on whether the primary tumour characteristics, hormone receptors and HER2 expression change as a result of chemotherapy. The present case report shows biomarker profile alteration in a case of high-grade breast carcinoma.