India, with an abundance of medicinal plants, holds a strong knowledge of herbal system where Ayurveda is the oldest medicinal system. The medicinal plants play vital role in disease prevention since they are rich source of phytochemicals. Phytochemicals are non- nutritive substances that have numerous health benefits. D. bulbifera is one such useful medicinal plant that belong to the family of Dioscoreaceae and is commonly known as Varahi Kanda, Kadu Kanda, Ratalu, Yam and Air potato. It has numerous traditional uses and its medicinal benefits have been reported in the Indian traditional systems of medicine. The present work encompasses phytochemical screening and evaluation of antibacterial and antioxidant activity of D. bulbifera tubers. The dried and powdered sample of tubers was subjected to Soxhlation using four different solvents in increasing order of their polarity. The phytochemical screening revealed the presence of variety of phytochemicals such as, alkaloids, phenols and tannins, flavonoids, glycosides etc. The phenol and flavonoid content of D. bulbifera was calculated by colorimetric method. The phenol content was found in great amount in ethanol extract, also the flavonoid content was maximum in ethanol extract. The antibacterial activity was evaluated by disc- diffusion method. D. bulbifera exhibited good antibacterial and antioxidant potential. The antioxidant potential, in terms of DPPH scavenging potential, was found maximum in ethanol extract, followed by water and chloroform extract. Maximum antibacterial activity was reported in chloroform extract against Klebsiella and in ethanol extract against E. coli.