Background: Otitis medium (OM) is a term used to refer to a group of complicated infectious and inflammatory disorders that affect the middle ear. There are several subtypes of OM, each with a unique presentation, set of consequences, and course of therapy. The purpose of the current study was to evaluate the pathologic and clinical features of chronic otitis media. Methods: The present investigation included a total of 25 individuals with a confirmed diagnosis of otitis media. Each individual had their middle ear discharge collected, deposited on thioglycollate broth medium, and immediately submitted for pathogenic analysis. Swab samples were cultivated on chocolate agar and 5% sheep blood agar to isolate aerobic bacteria, and they were then incubated aerobically at 37 °C for 24-48 hours. Different microbiological techniques were used to identify the isolated that were grown. SPSS software was used to analyze all of the findings. Results: The most noticeable clinical manifestation was observed to be ear pain and discharge. The additional symptoms that were discovered to be present were discomfort and deafness. When evaluating the pathogenic profile, it was found that 80%, 60%t, 64%, 48%, and 40% of the patients, respectively, included coagulase-negative staphylococci, S aureus, P aeruginosa, Klebsiella spp., and Proteus spp. The most prevalent microorganisms causing chronic otitis media are coagulase-negative staphylococci and S aureus, and the symptoms they present with include earache and ear discharge.