Background: Thyroid nodules are highly frequent, and the method used to diagnose them has a significant impact on prevalence rates. The present study was conducted to assess correlation of ultrasound and cytological findings in thyroid neoplasms using TIRADS and Bethesda system. Materials & Methods: 56 patients who have thyroid nodule in B-mode ultrasound and are scheduled to get an FNACof both genders were staged according to TIRADS. FNAC results are followed up for the Bethesda staging. Results: Out of 56 patients, males were 26 and females were 30. Age group 25-34 years comprised of 4, 35- 44 years 16, 45- 54 years 22 and >55 years 14 patients. The difference was significant (P< 0.05). Out of 32 TIRADS 2 nodules, 0 turned to be higher than Bethesda 4 (malignant). Out of 16 TIRADS 2 nodules, 2 were in Bethesda 1, 7 in 2, 1 in 3 and 1 in 4. Out of 6 TIRADS 4 nodules, 1 was in Bethesda 1, 3 in 2, 1 in 4, 2 in 5 and 1 in 6. Out of 2 TIRADS 5 nodules, 1 was in Bethesda 1, 1 in 2, 2 in 4, 3 in 5 and 2 in Bethesda 6. Conclusion: A considerable degree of confidence can be placed in the likelihood that a thyroid nodule is malignant if the TIRADS system is used by US to classify thyroid nodules correctly. Initiating the proper care of the nodule can be done without the need for unnecessary FNA procedures.