Background: Most commonly preterm very low birth weight babies require thermal support, infection control, surfactant support and nutritional support. One of the most challenging issues in the management of preterm very low birth weight infants is providing standard nutritional support. Optimal nutrition has been identified as a fundamental factor in reducing mortality and long term morbidities like extra-uterine growth restriction and poor neurodevelopment al outcome in preterm very low birth weight infants. So , the study is to determine the beneficial effects of early exclusive enteral feeding in stable very low birth weight babies. Results: Each group included 51 neonates. The incidence of feeding intolerance and sepsis was 15.7% and 5.9% in exclusive enteral feeding group where as in conventional feeding group the incidence of feeing intolerance and sepsis was 27.1 and 29.2. The difference was statistically significant when exclusive enteral feeding group was compared with conventional feeding group with p values 0.002 and 0.003 respectively. Duration of antibiotic therapy is also less in exclusive enteral feeding group. More babies of exclusive enteral feeding group does not received intravenous fluids where as in conventional feeding group all the babies received intravenous fluids so time taken to achieve total enteral feeds also high. The duration of hospital stay was less in exclusive enteral feeding group compred with conventional feeding group. Mean duration of hospital stay for exclusive enteral feeding group was 10.35 ± 4.93 where as in conventional feeding group was 13.88 ± 3.33. The difference was statistically significant with p value < 0.001. Conclusion: our study it was concluded that we can start exclusive enteral feeding without using intravenous fluids from the day one of life. The incidence of feeding intolerance and sepsis is also decreased in infants on exclusive enteral feeding. The need for central lines, antibiotic therapy and intravenous fluids can be decreased in infants on exclusive enteral feeding as compared to infants on conventional feeding. We can successfully start exclusive enteral feeding in stable very low birth weight infants, it is useful for early discharge of the infants without increasing the risk of sepsis and NEC.