Background: Interstitial lung disease (ILD) is a broad category of lung diseases that includes more than 130 disorders which are characterized by scarring and/or inflammation of the lungs. The present study was conducted to assess CT signs in usual interstitial pneumonia pattern of interstitial lung disease. Materials & Methods: 56 patients of interstitial lung disease of both genders were included. Cases were classified as connective tissue disease (CTD) and non- connective tissue disease (CTD). CT scan was performed in one of these three multi-slice CT scanners. CT scans were considered diagnostic quality if whole of thorax in full inspiration is covered. Parameters such as anterior upper lobe sign, exuberant honeycombing sign, straight edge sign etc. were recorded. Results: Group I had 18 males and 10 females and group II had 16 males and 12 females. Anterior upper lobe sign was present in 35%in group I and 62% in group II, exuberant honeycombing sign was present in 36% in group I and 63% in group II and straight edge sign was present in 30% in group I and 71% in group II. The difference was significant (P< 0.05). Sensitivity of CT in diagnosis of anterior upper lobe sign was 35%, exuberant honeycombing sign was 50% and straight edge sign was 40%. specificity of CT in diagnosis of anterior upper lobe sign was 82%, exuberant honeycombing sign was 74% and straight edge sign was 85%. Conclusion: EHC sign was the most sensitive sign and SE sign was the most specific sign.