Background: The main causes of mortality in non-coronary intensive care units (ICUs) include severe sepsis and septic shock, which are significant reasons for ICU admissions.The present study compared APACHE IV and SAPS II scoring in severe sepsis. Materials & Methods: 65 patients admitted to the ICU with severe sepsis and septic shock of both genders were recruited. Scoring system such as APACHE IV and SAPS II was used. Results: Out of 65 patients, males were 35 and females were 30. Diagnosis was congestive cardiac failure in 4, rheumatic heart diseasein 2, tetanus in 5, meningitis in 3, CNS sepsis in 2, cirrhosis of liver in 6, malignancy in 4, pneumonia in 18, tuberculosis in 6, COPD in 8, restrictive lung disease in 4 and ARDS in 3 patients. The difference was significant (P< 0.05). Conclusion: When comparing the mortality rates of individuals with severe sepsis, both methods APACHE IV and SAPS IIwere comparable.