Background: Patients with a healthy immune system show 90% and 95% success rates for dental implants, according to data from 10 years of follow-up. The present study was conducted to assess the success rate of dental implants in medically compromised patients. Material & methods: 58 medically compromised patients of both genders and an equal number of healthy subjects was taken as control. Parameters such as the amount of bone loss around the implant, signs of infection, and level of bone around the implant were recorded. The survival rate was recorded. Results: Group I had 23 males and 35 females with 86 dental implants. Group II had 25 males and 33 females with 90 dental implants. In group I, 24 patients were diabetic, 16 had hypertension, 4 had hypothyroidism, 10 had cardiovascular disease and 4 had osteoporosis. The difference was significant (P<0.05). The survival rate in group I was 65% and in group II was 92%. The difference was significant (P< 0.05). Conclusion: Patients such as diabetes, osteoporosis and hypothyroidism etc. had lower survival rate as compared to healthy subjects.