Background: The competency-based medical education (CBME) framework emphasizes the importance of developing practical skills in medical students. This study aimed to evaluate the effectiveness of a teaching module on intramuscular drug administration and communication skills in pharmacology according to the CBME curriculum at a government medical college in North Maharashtra. Methods: A pre- and post-test study design was used to evaluate the teaching module. The study included 50 medical students who were taught the module over a period of four weeks. The module included both theoretical and practical components, with a focus on developing communication skills and practical skills in intramuscular drug administration. The students' knowledge, skills, and attitudes were assessed before and after the module using a validated questionnaire. Results: The results showed a significant improvement in the students' knowledge, skills, and attitudes towards intramuscular drug administration and communication skills after the module. The mean score for the pre-test was 48.6%, which increased to 79.8% in the post-test. The students also reported increased confidence in their ability to communicate with patients and administer intramuscular drugs. Conclusion: The study highlights the importance of developing practical skills in medical students and the effectiveness of the CBME framework in achieving this goal. The teaching module on intramuscular drug administration and communication skills in pharmacology can be used as a model to develop similar modules for other practical skills in medical education.