Background: The largest and most intricate vascular network in the brain is the middle cerebral artery (MCA). The present study was conducted to assess variations in branching pattern of middle cerebral artery. Materials & Methods: 50 cadavers were studied. The internal carotid artery was identified and the origin of the middle cerebral artery was determined. Results: Length of M1 segment was >20 mm in 9, 17-19 mm in 8, 14-16 mm in 17, 11-13 mm in 10 and <11 mm in 4 cases. The difference was significant (P< 0.05). Outer diameter of M1 segment>5 mm was present in 4, 3-5 mm in 40 and <3 mm in 6 cases. The difference was significant (P< 0.05). Branching pattern of middle cerebral artery was bifurcation in 38, trifurcation in 10 and ramification in 2 cases. The difference was significant (P< 0.05). Conclusion: The bifurcation pattern was seen in the majority of cases. The M1 segment's length and diameter fell within the usual range.