Aim: To compare the outcome of dural closure between autologous pericranial graft and collagen matrix graft. Materials And Methods: The present prospective study was conducted at Indoor ward male and female, Department of neurosurgery, Bangur Institute of Neurosciences, IPGMER and SSKM Hospital, Kolkata from July 2021-December 2022 among 50 patients admitted with cranial Dural defect repaired. Out of 50 patients admitted with cranial dural defect repaired; 25 patients undergoing duragen assisted repaired and the remaining 25 patient’s pericranial graft repaired. Results: Most common etiology among the study subjects was tumour followed by trauma and vascular condition.Mean hospital stay (in days) was found to be 5.24±2.48 and 5.41±2.62 in duragen and pericranial graft group respectively.Only one subject suffered from postoperative complication in duragen group while the same was reported among 11 patients in pericranial graft group with statistically significant difference as p<0.05. Conclusion: There is a significant reduction in the time for doing cranial dural defect repair while using collagen matrix (DuraGen) for dural closure as compared with pericranial graft. Significant reduction in time for doing cranial dural defect repair might mean in itself a reduction in surgical trauma as well as duration of hospital stay.