Background: Rigid internal fixation with metallic elements has been a routine procedure. The present study was conducted to assess efficacy of biodegradable plating system for fixation of maxillofacial fractures. Materials & Methods: 56 cases of maxillofacial fractures of both genders were treated with Biodegradable Inion CPS (2.0 mm) plating system. Parameters such as location and type of fracture (displaced vs. nondisplaced), derangement of occlusion, paraesthesia along the distribution of infra-orbital nerve or mental nerve, presence or absence of diplopia, enopthalmos/exopthalmos in case of mid face fractures were recorded. Results: Out of 56 patients, males were 30 and females were 26. Etiological factors were RTA in 38, violence in 12 and fall in 6 cases. Type of fracture was angle in 8, ZMC in 25, parasymphysis in 3, Lefort- I in 1, lefort- II in 15 and lefort- III in 4 patients. Clinical features were deranged occlusion in 23, paraesthesia in 5, diplopia in 2 and enophthalmos in 4 cases. Complications were infection in 2 and malunion in 1 case. The difference was significant (P< 0.05). Conclusion: Biodegradable plates and screw system provided satisfactory stabilization when used as internal fixation for fractures of midface fractures in patients of all ages and mandibular fractures.