Background: Fibroids are muscular tumors that grow in the wall of the uterus. In this study we compared the abdominal hysterectomy and vaginal route of hysterectomy in fibroids. Materials & Methods: 80 cases with diagnosis of fibroid uterus requiring hyterectomy were equally divided in two groups. Group A (n = 40) includes those who underwent vaginal hysterectomy (non descent vaginal hysterectomy, NDVH) and group B (n = 40) includes those who underwent abdominal hysterectomy. Results were compared in terms of duration of surgery, complications, postoperative pain and hospital stay in both the groups. Results: The mean operating time for NDVH was 95 minutes and for TAH was 115.375 minutes. The difference was statistically very significant. The mean blood loss in NDVH surgery was 211.25 ml and for TAH surgery was 327.5ml. Only single case of bladder injury was there in TAH group. Incidence of blood transfusion was 10% i.e. 2.5% in NDVH group and 17.5% in TAH group. There were more intraoperative complications noted in TAH group (20%) in comparison with NDVH group (2.5%). Postoperative complications were seen more with TAH group(55%) in comparison with NDVH group(2.5%). UTI, fever and wound sepsis these all complications only were seen in TAH group. Postoperative blood transfusion incidence was 2.5% in NDVH group and 15% in TAH group. Pain score on day 3 (VAS) was between 0-3cm in 38 patients in NDVH group and was between 4-6cm in TAH group. Mean pain score was 0.9 cm in NDVH group and it was 4.08 cm in TAH group. The mean hospital stay of NDVH group was 5.18 days and for TAH group was 9.23 days. Maximum cases from NDVH group were discharged by 5th day (82.5%) and from TAH group maximum cases were discharged within 6 to 10 days (87.5%).P value of mean was statistically very significant (P value =<0.0001). Conclusion: Route of hysterectomy depends on choice, experience and expertization of surgeon and these things varies from individual to individual. Abdominal route was still most preferred route for hysterectomy.