Background: Pancreatic lesions refer to abnormal growths or changes in the tissue of the pancreas. The present study compared ultrasonography and computed tomography in evaluation of retroperitoneal masses. Materials & Methods: 90 patients of retroperitoneal masses of both genders underwent Ultrasound and MDCT. Parameters such as size, appearance, echotexture, vascularity and other findings were studied. Results: Out of 90 patients, males were 50 and females were 40. Clinical features were pain in abdomen in 36, lump in abdomen in 7, fullness of abdomen in 14, loss of appetite in 28, trauma in 3 and weight loss in 17 patients. The difference was significant (P< 0.05). Adrenal adenoma was detected correctly in 8 and 10, aortic aneurysm in 9 and 7, pheochromocytoma in 7 and 7 by USG and MDCT, renal abscess in 18 and 16, renal hematoma in 8 and 4, RCC in 7 and 7, complex renal cyst in 11 and 11 and pancreatic carcinoma in 10 and 7 respectively. The difference was non- significant (P> 0.05). Conclusion: For the purpose of assessing retroperitoneal lesions, USG is advised as a primary screening method, while CT is advised as a confirmatory method for determining the full extent of the lesion.