The use of medicinal plants have been constant since the time of immemorial and the success of modern medical science largely depends on drugs originally obtained from natural resources, to such a degree that the World Health Organization (WHO) recognizes its important value. Kumkum is one of the medicinal plants from Garhwal Himalyan range was screened for the presence of major phytochemical compounds and also analyzed for their antioxidant activity. Klebsiella pneumoniae, a proteobacterian, an extremely resilient bacterium whose success as a pathogen seems to follow the model of “the best defense for a pathogen is a good defense” rather than “the best defense for a pathogen is a good offense”. The 70% methanolic & ethanolic extracts of medicinal plants were prepared via, maceration process. Further, phytochemical analysis of each extract was considered & Kirby-Bauer Disk Diffusion Susceptibility Test was followed simultaneously. The results showed to be positive with maximum of the phytochemical tests i.e. alkaloids, carbohydrates, saponins, tannins, proteins, resin, phenols, later conducted disc diffusion showed susceptible zone of inhibition. Concluding as, the ethanol extracts of Kumkum have shown appreciable antimicrobial activities against Klebsiella pneumoniae.