Background: To compare the efficacy of Neural Therapy and Physical Therapy in Chronic Low Back Pain. Materials & methods: A total of 100 patients were enrolled. Random division of the patients was done into two study groups: Group A- Patients who were scheduled to undergo physiotherapy, and Group B- Patients among which previous session of physiotherapy failed to relieve the symptoms. In the physical therapy programme, the lumbar region was heated superficially (using hot packs), deeply (using ultrasound), and analgesically (using transcutaneous electrical nerve stimulation, or TENS). The physical therapy program was applied five times a week for three weeks. Among patients of group B, neural therapy (NT) was carried out. Local injection treatment (1:1 mixture of Lidocaine HCl and saline) for five sessions. Analysis of result was done using SPSS software.Results: Among patients of group A, mean VAS at pre-treatment and post-treatment was 7.95 and 4.28 respectively. Among patients of group B, mean VAS at pre-treatment and post-treatment was 7.51 and 4.02 respectively. Non-significant results were obtained while comparing the VAS at both the time intervals in between the two study groups. Among patients of group A, mean RMDQ at pre-treatment and post-treatment was 15.35 and 9.12 respectively. Among patients of group B, mean RMDQ at pre-treatment and post-treatment was 16.12 and 8.92 respectively. Non-significant results were obtained while comparing the RMDQ at both the time intervals in between the two study groups. Conclusion: Among patients with chronic low back pain, both of Neural therapy and physiotherapy are effective.