Transforaminal epidural steroid injection (TFESI) is a non-operative treatment option for lower limb radicular pain caused by different pathologies, including lumbosacral prolapsed intervertebral disc (PIVD), canal stenosis and recurrent PIVD. The aim of study was to assess the outcome of TFESI in conservatively managed patient of lower limb radicular pain. The technique involved fluoroscopic guidance and needle placement targeting the affected root in safe triangle by conventional approach. Retrospective data of 54 patients was analysed, assessing pain intensity using Visual Analog Scale (VAS) before, 30 minutes, 15 days, one month, three month and six month after the procedure. Results indicated significant pain reduction following TFESI, with mean VAS scores decreasing form 8.9 before the procedure to 0.82, 30 minutes after the procedure. At follow-up period of 15 days, one month, three month and six month, none of TFESI patient reported lower limb pain. Complication were minimal, and the study suggested that TFESI is effective in both diagnostic and therapeutic roles for various pathologies causing radicular lower limb pain. TFESI is an effective procedure for radicular lower limb pain caused by variety of pathologies. Procedure related complications are minimal. For foraminal and extraforaminal lumbosacral PIVD this may be considered for both diagnostic as well as therapeutic role.