Background: Laryngoscopy and tracheal intubation are unpleasant stimuli that cause a brief but noticeable sympathetic reaction that increases heart rate (HR), blood pressure, and other symptoms. The present study assessed effect of esmolol & dexmedetomidine in attenuating haemodynamic response to laryngoscopy and endotracheal intubation. Materials & Methods: 60 adult patients scheduled for elective surgery under general anesthesia were divided into 3 groups. In groupI, 10 ml normal saline was administered 5 minutes before laryngoscopy and intubation.Group II patients received 0.5 mg/kg esmolol IV diluted to 10 ml with distilled water, 5 minutes before laryngoscopy and intubation. In group IIII, patients received 0.5µ/kg of dexmedetomidine IV diluted with distilled water to make 10 ml, 5 minutes before laryngoscopy and intubation. Parameters such as duration of laryngoscopy, HR (BPM), SBP (mmHg), DBP (mmHg), MAP (mmHg), RPP (mmHg/min) X 100, mean dose of propofol, RSS and VASwas recorded. Results: Age group 20-30 years had 4 in group I, 6 in group II and 5 in group III, age group 31-40 years had 6, 7 and 5, 41-50 years had 9, 5 and 6 and 51-60 years had 11, 12 and 14 patients respectively. The duration of laryngoscopy was 10.5, 10.8 and 10.7, HR (BPM) was 87.2, 87.4 and 87.2, SBP (mmHg) was 129.6, 128.3 and 126.5, DBP (mmHg) was 78.5, 79.2 and 80.0, MAP (mmHg) was 95.5, 96.3 and 97.2, RPP (mmHg/min) X 100 was 112.4, 117.3 and 114.1, dose of propofol was 101.8, 102.2 and 76.5, RSS was 2.3, 2.1 and 2.7 and VAS was 4.6, 4.0 and 2.7 in group I, II and III respectively. The difference was non- significant (P> 0.05). Conclusion: Intravenous dexmedetomidine attenuated the stress response to laryngoscopy and intubation and maintains haemodynamic stability during the intraoperative period. Dexmedetomidine 0.5 mcg/kg attenuated the haemodynamic response to laryngoscopy and intubation more effectively and maintains intraoperative haemodynamic parameters more stable.