Background: Surgical site infection is one of the most common causes of the morbidity and mortality in postoperative patients. Surgical antibiotic prophylaxis (SAP) has been a boon in the prevention of surgical site infections (SSIs). Aim: To evaluate the utilization of antimicrobial prophylaxis in surgical patients at a tertiary care hospital. Materials and methods: The study included a cohort of 100 patients. This study included individuals of all genders and ages who had undergone a surgical procedure, as well as patients who were willing to provide informed consent. The data were collected in accordance with a standardized format, developed based on the criteria established by the World Health Organization (WHO). This format encompassed various aspects, such as the demographic characteristics of the patients, the antimicrobial prescriptions given from the time of admission to discharge, and the examination of operative notes to identify instances of antimicrobial administration during surgery. Results: Almost, all the patients (96%) receive intravenous preoperative antimicrobial dose on the day of surgery. Most commonly prescribed 80(80%) antimicrobials were third‑generation cephalosporins, followed by aminoglycosides 38 (38%). Ceftriaxone was the most frequently prescribed antimicrobial in 76(76%) patients. Among these, the most commonly prescribed group was the third‑generation cephalosporin (75%). While individually amikacin (60%) was the most commonly prescribed individual AMA followed by ceftriaxone (45%) and metronidazole (53%). Fixed‑dose combinations were also frequently used; among them piperacillin‑tazobactam (22%) was the most common combination used followed by the ceftriaxone‑sulbactam (21%) and amoxy‑clavulanic acid (14%). Conclusion: The findings of the current investigation indicate a notable lack of adherence to SAP-stranded guidelines, particularly with regards to the extended utilization of antimicrobial agents following surgery.