Background: Traumatic brain injury is a significant issue for public health. The present study was conducted to assess correlation of D-dimer and progressive haemorrhagic injury. Materials & Methods: 58 patients of traumatic brain injury (TBI) of both genders were studied. Parameters such as injury time, mechanism of injury, systolic blood pressure, and GCS score were recorded. 5 ml venous blood was taken and the plasma D-dimer level was evaluated. Results: Out of 58 patients, males were 38 and females were 20.PHI positive and PHI negative patients, mean time from injury to the first CT scan was 1.6 hours and 2.3 hours, time between the first and second CT scan was 8.2 hours and 9.3 hours. D-dimer level was 6.5 mg/L and 2.1 mg/L, APTT was 26.4 seconds and 25.2 seconds, PTINR was 1.05 and 1.01, PLT was 156.3X109/L and 191.2X109/L, PT was 13.2 seconds and 11.7 seconds respectively. The stepwise logistic regression showed that when D-dimer values were dichotomized at 5 mg/L, time from injury to the first CT scan was no longer a risk factor statistically while the OR value of D-dimer to the occurrence of PHI elevated to 11.9. Conclusion: Several clinical and laboratory data can be used to predict the development of PHI within hours after the injury. A high D-dimer level implies fibrinolysis, and the occurrence of PHI is particularly likely to be predicted by a compensatory response to hypercoagulation at the time of admission. Key words: Progressive hemorrhagic injury, Traumatic brain injury, D-dimer.