Introduction: Radio-diagnosis plays an important role in the dental practice management process, so there is a need to have an advanced diagnostic modality to detect the pathology at an early stage and provide the best possible treatment to the patient. Method: In order to provide the best possible therapeutic outcome, we discussed 222 cases of maxillofacial pathologies that were identified using cone beam computed tomography (CBCT). Aim: To determine if CBCT is a valuable imaging modality for diagnosing patients with maxillofacial pathology. Result: CBCT scans revealed pathologies such as radicular cysts, residual cysts, dentigerous cysts, maxillary sinusitis, odontogenic keratocysts, Langerhans cell histiocytosis, Osteomyelitis, Fibro-osseous lesions, Stafne bone cyst, fractures, Ameloblastomas, Sialoliths, Aneurysmal bone cyst, TMDs and maxillofacial malignancies. Conclusion: CBCT proved to be very essential in assessing various radiological changes in patients with maxillofacial pathologies , thereby improving patient care and ensuring low morbidity associated with resection. Keywords: Cone-Beam Computed Tomography, advanced therapeutic diagnosis, maxillofacial pathologies.