Introduction: The low serum zinc levels in patients with liver cirrhosis are due to decreased intake, decreased absorption, decreased bioavailability, and increased losses. There is also reduced liver protein synthesis in patients with liver cirrhosis. Decreased zinc levels may be a precipitating factor for hepatic encephalopathy. Aims and Objectives: To study the level of zinc in decompensated chronic liver disease and to study correlation of serum zinc levels with various stages of hepatic encephalopathy in decompensated chronic liver disease. Materials and Methods: This cross-sectional study was conducted in 50 patients of decompensated chronic liver disease admitted or attending the Medicine Emergency or Outpatient Department (OPD) of General Medicine in Guru Nanak Dev Hospital attached to Government Medical College, Amritsar. The study was carried out after seeking permission from Institutional Ethics Committee, Government Medical College, Amritsar. Detailed history and physical examination and biochemical tests were done. Written informed consent was obtained from the patients. Conclusion: The present study concluded that mean serum zinc levels were low in DCLD patients and it decreased significantly with worsening of hepatic encephalopathy grades. The study found out that there was a significant association between serum zinc levels and grades of hepatic encephalopathy. The study raises a possibility that decrease in serum zinc levels can have a role in the development of hepatic encephalopathy and zinc supplementation may have a beneficial role in the treatment of hepatic encephalopathy.