INTRODUCTION: Chronic liver disease is a dynamic process of inflammation, destruction and regeneration of liver parenchyma, which leads to fibrosis and cirrhosis. Cirrhosis is the final stage of chronic liver disease. Hyperuricemia is a risk factor for the development of cirrhosis. Proposed mechanisms include induction of endothelial dysfunction, insulin resistance, oxidative stress, and systemic inflammation which are now known to be important risk factors for the development or progression of liver diseases. AIMS AND OBJECTIVES: The present study was designed to estimate the serum uric acid levels in patients of chronic liver disease and to determine and study the correlation between serum uric acid levels and Child-Turcotte-Pugh (CTP) score in patients presenting with chronic liver disease. MATERILAS AND METHOD: The present cross-sectional study was conducted on 50 patients of chronic liver disease that presented to Medicine Department (indoor/outdoor department) of Guru Nanak Dev Hospital, attached to Government Medical College, Amritsar. A Detailed history and thorough physical examination were done after taking informed consent. Serum uric acid, liver function test and other appropriate investigations were performed. CTP score calculated and statistical analysis were done. RESULTS: Among 50 patients in this study, majority of them were male constituting 82% (n = 41). Females were 18 % (n = 9). Male: Female was 4.5:1.Among 50 cirrhotic patients, most of the patients belonged to CTP class C (44%) followed by CTP class B (40%) and then by CTP class A (16%).The mean serum uric acid of study population was 6.45±2.25 mg/dl. CTP score was used to assess the severity and prognosis of cirrhosis of liver in this study. In CTP class A, the mean serum uric acid level was 4.42±1.18 mg/dl. In class B and class C, the mean serum uric acid levels were higher: 5.49±1.49 mg/dl and 8.07±2.04 mg/dl respectively. The difference was statistically significant (p value=0.001).Pearson's correlation coefficient was used to assess the relation between serum uric acid level and CTP score and there was a positive correlation between the two variables with r value of 0.7 and p value of 0.001. CONCLUSION: This study established a statistically significant positive correlation between serum uric acid levels and CTP score.