The methanolic extract of Blumea lanceolaria (Roxb.) Druce (200 and 400 mg/kg) was evaluated for analgesic, antipyretic and anti-inflammatory properties in mice and rats. The extract doses of ( 200 and 400 mg/kg) showed significant (p < 0.01) analgesic, antipyretic and anti-inflammatory activities were observed in all the experimental models tested. The extracts may be exerting its effects through central mechanisms. These findings confirms its ethnomedicinal use of the plant in the treatment of pain, fever and inflammation. The current results proved that the plant Blumea lanceolaria (Roxb.). Druce traditionally used by the tribal people of Mizoram is having good potential for analgesic, antipyretic and anti-inflammatory activities.