Acute pancreatitis is an inflammatory process of the pancreas with varying involvement of regional tissues or remote organ systems and with potentially devastating consequences. CRP is an acute phase protein and plasma levels increase in nearly all acute and chronic inflammatory diseases. Thus, the aim of the study was to identifying the role of c-reactive protein in severity stratification of acute pancreatitis. The study was conducted on 50 patients. The results showed that mean age of the patients was 42.82±12.29 years. Majority of patients belonged to 41-50 age group followed by 31-40 age group.Majority of patients were male (52%) and the remaining were females (48%). Most common presenting symptoms were pain, vomiting, abdominal distension and vomiting with pain being reported in majority of patients (96%). It was observed that alcohol was the most common cause of acute pancreatitis as it was seen in 72% of patients.Mortality was seen in 1 patient (2%). It was observed that there was significant correlation coefficient ratio between CRP and hematocrit, calcium ,BUN and creatinine.It was observed that majority of patients with CRP level > 150 mg/l had severe acute pancreatitis (p value=0.0004). Overall, these findings highlight the potential utility of CRP in the management of acute pancreatitis and suggests that it may be a useful tool in helping to guide treatment decisions.