Aim:The aim of this study was to explore the psychological impact of infertility on women and to identify the coping mechanisms they employ in response to emotional distress. This research aimed to provide insights into the emotional challenges faced by women with infertility and the strategies they use to manage these challenges. Materials and Methods:The study involved 120 women aged between 25 and 45 years, experiencing infertility, recruited through fertility clinics, support groups, and social media platforms. Participants completed a demographic questionnaire, psychological impact assessments using the Infertility Distress Scale (IDS) and Hospital Anxiety and Depression Scale (HADS), and a Coping Mechanism Inventory. A subset of 30 participants also participated in in-depth semi-structured interviews. Data were analyzed using descriptive statistics, correlational analysis, and thematic analysis. Results:The majority of participants were aged 31-35 years (39.2%) and had primary infertility (65.8%). Psychological distress was high, with 43.3% reporting moderate distress and 41.7% experiencing severe distress. Anxiety (mean score = 10.4) and depression (mean score = 8.7) were prevalent, with a combined score of 19.1 indicating significant emotional burden. Social support was the most common coping strategy (80%), followed by emotion-focused coping (70%) and problem-focused coping (60%). Multiple regression analysis revealed that the duration of infertility and the type of infertility were significant predictors of psychological outcomes, with longer durations and primary infertility associated with higher levels of distress. Conclusion:Infertility significantly impacts women's mental health, with anxiety, depression, and emotional distress being prevalent. Social support plays a key role in coping, but a lack of support was reported by some women. The duration and type of infertility are critical factors influencing psychological distress. Targeted psychological support is essential, particularly for those with prolonged or primary infertility.