Airwaymanagementisoneofthemostimportantskillsofthephysician; failuretoproviderequiredairflowcancausedeathorsequelaeofthepatient,especially in emergency conditions. The control of circulation and intubation, without losing time, in cardiac and respiratory arrest, saves the patient from hypoxia, improving quality of life in the long term.The present Prospective randomized double blinded study was carried out in 60 Patients admitted for surgeries under general anaesthesia in department of surgery, ENT, orthopaedics r selected for variouselectivesurgical procedures with American Society of Anaesthesia (ASA) physical status I and II. Dexmedetomidine is superior and better drug compared to fentanyl to reduce haemodynamic response i.e., attenuation of pressor response to laryngoscopy and tracheal intubation with single premedication dose.